How effective is Kybella at improving double chin (submental fat)?
In a study of 506 patients who had moderate or severe (grade 2 or 3) submental fullness, patients received either KYBELLA (up to 6 treatments) or placebo at no less than 1-month intervals. The severity of submental fullness was based on a 5-point grading scale with 0 being none and 4 being extreme. At baseline, 51% had a clinician-rated submental fat severity of moderate and 49% had a severe submental fat rating. 0.2 mL was administered into the submental fat tissue with each injection site spaced 1 cm apart (2 mg/cm2). Maximum of 100 mg (10 mL) was permitted over the entire treatment area.
The efficacy of Kybella was based on at least 1-Grade and 2-Grade improvements in submental fullness on the clinician-reported and patient-reported rating scales 12 weeks after the final treatment. 70% of Kybella treated patients versus 18.6% of patients that received placebo had at least 1-grade reduction on both the clinician-reported and patient-reported ratings of submental fat improvement. 13.4% of treated patients versus <0.1% patients that received placebo had at least a 2 grade reduction on both clinician-reported and patient-reported ratings of submental fat improvement. In a subset of patients, more Kybella treated patients (43%) achieved at least a 10% reduction in submental fat volume compared to placebo (5%) when evaluated by MRI.
Interesting facts about Kybella
What are side effects of Kybella?
Common side effects reported with Kybella include:
Injection site swelling
Trouble swallowing (dysphagia)
Facial (marginal mandibular) nerve injury, resulting in an asymmetric smile or facial muscle weakness may occur.
Next: Dosage, Drug interactions, Warnings, Pregnancy, Breastfeeding, Cost