How effective is Jardiance?

986 patients with uncontrolled type 2 diabetes and HbA1c (blood sugar average for the last three months) between 7-10% were studied in a 24-week trial. They received Jardiance 10 mg, Jardiance 25 mg, or placebo (a sugar pill).

• Jardiance 10 mg group: 35% achieved an HbA1c <7%, a decrease of 19 mg/dL in fasting blood glucose, and a body weight decrease of 2.8%.
• Jardiance 25 mg group: 44% achieved an HbA1c <7%, a decrease of 25 mg/dL in fasting blood glucose, and a body weight decrease of 3.2%.
• Placebo group: 12% achieved an HbA1c <7%, a decrease of 12 mg/dL in fasting blood glucose, and a body weight decrease of 0.4%

A total of 637 subjects with inadequately controlled type 2 diabetes and an HbA1c between 7-10% and already on metformin participated in a 24-week study. They were placed in a group either taking a combination of Jardiance 10 mg plus metformin, Jardiance 25 mg plus metformin, or placebo plus metformin.

• Jardiance 10 mg plus metformin: 38% achieved an HbA1c <7%, a decrease of 20 mg/dl in fasting blood glucose, and a body weight decrease of 2.5%.
• Jardiance 25 mg plus metformin: 39% achieved an HbA1c <7%, a decrease of 22 mg/dL in fasting blood glucose, and a body weight decrease of 2.9%
• Placebo plus metformin: 13% achieved an HbA1c <7%, a decrease of 6.0 mg/dL in fasting blood glucose, and a body weight decrease of 0.5%

Interesting Facts about Jardiance

• Jardiance is the third SGLT-2 inhibitor approved by the FDA.
• Jardiance can increase cholesterol (LDL-C).
• The glucose lowering effect of Jardiance is reduced in people with low kidney function. 

What are the side effects of Jardiance?

• Hypoglycemia (low blood sugar, if taken with another blood glucose lowering agent)
• Frequent urination
• Urinary tract infections
• Yeast infections
• Dehydration
• Kidney problems
• Increase in cholesterol
• Low blood pressure

Next: Dosage, Drug Interactions, Warnings, Cost

Read: Effect Of Jardiance (empagliflozin) On Heart Attacks, Strokes, And Death In People With Type 2 Diabetes